EFFICACY OF ASCORBIC ACID (VITAMIN (J ON EXPERIMENTAL COPPER INTOXICATION IN TILAPIA ZILLII

EFFICACY OF ASCORBIC ACID (VITAMIN (J ON

EXPERIMENTAL COPPER INTOXICATION IN TILAPIA ZILLII

By
K.S. GHAZALY·
“Department of Natural History, Faculty of Education, University of Alexandrhl,

Alexandria, Egypt.

Key Words: Effect of Ascorbic acid on copper intoxication.

ABSTRACT
The i’?f!lIellces (?f two d~fferellt COllcelltratiollS (!f Ascorhic acid 011 the
experimelltal Copper illtoxication ill Tilapia zil/ii was illvestigated Ascorhic
acid has beell showll to have protective alld therapeutic effects against (‘opper
illtoxication The efficaq (!f Ascorhic acid was more clearly illdicated ill
Tilapia by a reductioll ~f mortality, ahsellce (?fpoisolling signs, lowered metal
cOlltellt (~f tisslles and prevelltillg the inhibition (?f blood GOT and LDH
acth’ities. Treatment with a cOllcelltration (?f 0..132 ppm Ascorbic acid was most
effective than the other treatment (0.216 ppm Ascorbic acid) ·which appeared
to have less preventive effect on Copper intoxication 111 hlood, liver, kidlley,
gills, muscle alld brain, Ascorbic acid illteracted with Copper ill some way
prevent tissue deposition Enhallced tramport of Copper to kidney was most
pronoullced at d~fferellt COllcelltratioll.\ (!fAscorbic acid as shown hy the metal
level ill each tissue. The present results demollstrate that Ascorhic acid has
bemfOlllld to he all effecth’e alltidote (!l Copper illtoxicatioll.