DEPRESSION OF PROTEIN SYNTHESIS IN TILAPIA BY AFLATOXIN

DEPRESSION OF PROTEIN SYNTHESIS IN TILAPIA BY
AFLATOXIN
By
N. A. SABER*
*National Institute of Oceanogr. & Fisheries, Alexandria-Egypt.
Key words: Physiology, Pollution, Tilapia.
ABSTRACT
Experimental ajlatoxicosis was induced in fingerlings Tilapia
nilotica by feeding them with dietQlY ajlatoxin (AF) BI at the levels of
0: -176.19,952.38 and 1954.76f-Lg/kgmofbasicdietforaperiodofI4
weeks. Results indicated that total serum protein was significantly
decreased in AF treated groups. The same trend was observedfor
serum albumin and total globulins at the levels of952. 88 and 1954. 70 f-L
g/kg, wheares at the low level (476.19 f-Lg/kg), the decrease was not
significant. Also, the results revealed a significant decrease (P .s 0.01)
in the globulin fractions (alpha and Beta), which reached to 61 % and
64 % in the fourth treated group respectively. Meanwhile, the gamma
globulin fraction showed significant increase (P < 0.05) at the level 476. 19 f-Lg/kg AF., but significantly decreased at the high doses of AF(BI}. Regarding the enzymatic activities (Serum, choline esterase, lactic dehydroganase, alanine amino transferase and Aspartarte amino transferase), the acetyl choline esterase (ACHE) was significantly decreased in the AF treated groups after the experimental period. On other hand,· the activities oflactic dehydrogense (LDH), alanine amino transferage (Al-tase) and aspartase amino transferase (As-tase) were significantly increased in AF treated groups.